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Institute for Advanced Academic Research / Graduate School of Medicine, Chiba University
LecturerThe molecular mechanism of carcinogenesis mediated by extrachromosomal DNA (ecDNA) remain largely unknown, despite increasing interest in this area in recent years. Previous studies have identified the presence of ecDNA in virus-associated cancers, where segments of the human and viral genomes are fused to form human-viral hybrid ecDNA (hybrid ecDNA). These studies have also suggested that hybrid ecDNA may play a critical role in tumorigenesis. My current research aims to elucidate the oncogenic functions of hybrid ecDNA by performing multi-omics analyses of clinical specimens and integrating clinical imaging, nutritional information, and other datasets. Through this work, I seek to develop novel therapeutic strategies to overcome virus-associated cancers.
Recent Topics of Interest:
extrachromosomal DNA (ecDNA), Spatial transcriptome analysis, AI
Motto in Research or in Life:
Always strive to stay one step ahead of the status quo
Hobby / Holiday:
Enjoy playing baseball and soccer, appreciating art, and discovering natural wine
Graduate School of Medicine, Chiba University
ProfessorMy goal is to elucidate the cellular and molecular mechanisms underlying diseases caused by immune system overreactions, such as allergic conditions including bronchial asthma and autoimmune diseases like rheumatoid arthritis. I aim to develop treatments based on these findings.
I am particularly interested in understanding the mechanisms that control T cell activation, which plays a central role in immune system dysregulation, and exploring the epigenetic regulation of immune memory.
Recent Topics of Interest:
(1) Understanding the cellular and molecular mechanisms underlying the development of allergic diseases, including asthma
(2) Investigating the cellular and molecular mechanisms involved in the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus
(3) Advancing treatments for allergies and autoimmune diseases through immune memory resetting strategies
Motto in Research or in Life:
Research motto
(1) I prioritize ‘intriguing’: I aim for research that is not only ‘intriguing’ medically but also biologically.
(2) I cherish the unexpected: I consider our hypotheses to be as small as grains of sand in the 4.6 billion years of Earth's history.
Motto in life
(1) I avoid turning down work whenever possible, but as a result, I am finding it increasingly difficult to do what I truly want.
(2) I try not to say “I have no choice" as much as possible; however, as a consequence, there’s a buildup of situations where it just can’t be helped.
(3) I strive not to make enemies, or at least that's my intention.
Hobby / Holiday:
Watching wombat videos, Traveling, especially visiting shrines and temples, Jogging during a trip, Visiting art galleries and museums
Graduate School of Medicine, Chiba University
Associate ProfessorI embarked on an academic path driven by my fascination with stem cells, renowned for their remarkable regenerative and differentiation capabilities. Presently, I am dedicated to advancing research in regenerative medicine and developing pathological models utilizing various types of human stem cells, with the ultimate goal of their clinical application in medical treatments.
Recent Topics of Interests:
Regenerative medicine, Hematopoietic stem cells, Aging-related diseases, Rejuvenation of an organism
