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Chiba University Hospital
Pharmacy Division Chair / ProfessorMy research focuses on addressing various challenges encountered in clinical practice at the Division of Pharmacy, of Chiba University Hospital, and the Department of Clinical Pharmacy at the Graduate School of Pharmaceutical Sciences.
Specifically, I conduct both basic and clinical analyses to design drug administration strategies for critically ill patients in intensive care units and those with rare diseases.
Additionally, I am engaged in basic research on vascular cells that contribute to the onset and progression of atherosclerosis, a major underlying cause of myocardial infarction and stroke. Through these works, I aim to generate novel evidence that is currently unavailable in medical practice and, in the near future, contribute to drug development initiatives originating from our division.
Recent Topics of Interests:
Adult deterioration
Cultivating critical thinking skills
Motto in Research or in Life:
Steady but unrelenting efforts
Hobby / Holiday:
Farming and meticulous cleaning
Institute for Advanced Academic Research / Graduate School of Medicine / Research Institute of Disaster Medicine, Chiba University
ProfessorThe genome is the blueprint of life. The “which part” of the genome is read differs in each cell, and the addition or deletion of the methyl group CH3- (just four atoms) plays an important role in reading the genome. This mechanism is known as epigenetic modification, and the development of next-generation sequencing technology has greatly contributed to this research field. Epigenetic modifications by methyl groups can be classified into two types: (1) methylation of histones and (2) methylation of DNA cytosines. Our previous research showed that histone methylations regulated by the Polycomb and Trithorax group proteins are essential for immune responses, particularly those mediated by T cells. In addition, our recent international collaborative study revealed that TET enzymes, which convert methyl-cytosine into hydroxymethyl-cytosine, inhibit inflammation and tumor development in mice and humans. Currently, our study focuses on the relationship between age-related epigenetic abnormalities and immune diseases, which has received much attention in recent years. The final goal of my research is to solve the mysteries of life and ultimately control diseases by concentrating our wisdom on physics, chemistry, and mathematics.
Recent Topics of Interests:
Cancer immunotherapy by epigenetic manipulation, Immuno-aging caused by epigenetic abnormalities, Integrative single-cell multi-omics analyses
Motto in Research or in Life:
The motto in research: Let’s enjoy science!
The motto in life: “If you put your mind to it, you could accomplish anything.” This quote is cited from Back to the Future, Universal Pictures, 1985.
Hobby / Holiday:
Reading books, Watching baseball games, Insect hunting
