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Graduate School of Medicine, Chiba University
ProfessorI am engaged in research to develop innovative cancer treatments using immune cells, specifically exploring the intricate relationship between cancer and the immune system as a mechanism of its effectiveness. Moreover, I am vigorously conducting efforts, including clinical trials, to swiftly provide treatment to patients in need.
Recent Topics of Interests: Tumor immunology research
Motto in Research or in Life:
There is no need for "For now" or "Sort of."
If I'm going to work on it, I'll give it my all.
Hobby / Holiday:
Reading, Practicing Volleyball for a Senior Volleyball Tournament
Graduate School of Medicine, Chiba University
ProfessorMy goal is to elucidate the cellular and molecular mechanisms underlying diseases caused by immune system overreactions, such as allergic conditions including bronchial asthma and autoimmune diseases like rheumatoid arthritis. I aim to develop treatments based on these findings.
I am particularly interested in understanding the mechanisms that control T cell activation, which plays a central role in immune system dysregulation, and exploring the epigenetic regulation of immune memory.
Recent Topics of Interest:
(1) Understanding the cellular and molecular mechanisms underlying the development of allergic diseases, including asthma
(2) Investigating the cellular and molecular mechanisms involved in the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus
(3) Advancing treatments for allergies and autoimmune diseases through immune memory resetting strategies
Motto in Research or in Life:
Research motto
(1) I prioritize ‘intriguing’: I aim for research that is not only ‘intriguing’ medically but also biologically.
(2) I cherish the unexpected: I consider our hypotheses to be as small as grains of sand in the 4.6 billion years of Earth's history.
Motto in life
(1) I avoid turning down work whenever possible, but as a result, I am finding it increasingly difficult to do what I truly want.
(2) I try not to say “I have no choice" as much as possible; however, as a consequence, there’s a buildup of situations where it just can’t be helped.
(3) I strive not to make enemies, or at least that's my intention.
Hobby / Holiday:
Watching wombat videos, Traveling, especially visiting shrines and temples, Jogging during a trip, Visiting art galleries and museums
Graduate School of Medicine, Chiba University
LecturerI am currently engaged in basic cancer research, with a particular focus on T cell-mediated anti-tumor immune responses in tumor-draining lymph nodes. I truly hope our research will contribute to developing innovative cancer immunotherapies.
Recent Topics of Interests:
・Fate determination of tumor-specific CD8T cells
・Molecular function of an activation marker CD69
Motto in Research or in Life: If Winter comes, can Spring be far behind?
Hobby / Holiday: Spending time with family, Exercising
Institute for Advanced Academic Research / Graduate School of Medicine / Research Institute of Disaster Medicine, Chiba University
ProfessorThe genome is the blueprint of life. The “which part” of the genome is read differs in each cell, and the addition or deletion of the methyl group CH3- (just four atoms) plays an important role in reading the genome. This mechanism is known as epigenetic modification, and the development of next-generation sequencing technology has greatly contributed to this research field. Epigenetic modifications by methyl groups can be classified into two types: (1) methylation of histones and (2) methylation of DNA cytosines. Our previous research showed that histone methylations regulated by the Polycomb and Trithorax group proteins are essential for immune responses, particularly those mediated by T cells. In addition, our recent international collaborative study revealed that TET enzymes, which convert methyl-cytosine into hydroxymethyl-cytosine, inhibit inflammation and tumor development in mice and humans. Currently, our study focuses on the relationship between age-related epigenetic abnormalities and immune diseases, which has received much attention in recent years. The final goal of my research is to solve the mysteries of life and ultimately control diseases by concentrating our wisdom on physics, chemistry, and mathematics.
Recent Topics of Interests:
Cancer immunotherapy by epigenetic manipulation, Immuno-aging caused by epigenetic abnormalities, Integrative single-cell multi-omics analyses
Motto in Research or in Life:
The motto in research: Let’s enjoy science!
The motto in life: “If you put your mind to it, you could accomplish anything.” This quote is cited from Back to the Future, Universal Pictures, 1985.
Hobby / Holiday:
Reading books, Watching baseball games, Insect hunting
Graduate School of Medicine, Chiba University / Research Center for Child Mental Development
Professor / DirectorI am researching cognitive-behavioral therapy, which is a psychotherapy that aims to help people, including Adolescents and Young Adults (AYA generation), manage their emotional problems by changing negative thinking habits and behavioral patterns for better mental health.
Recent Topics of Interest: "Memory Rescripting"
Motto in Research or in Life: There is no pleasure without pain. Fall down seven times, stand up eight.
Hobby / Holiday: Watching movies
Institute for Advanced Academic Research / Graduate School of Medicine, Chiba University
Associate ProfessorMy research aims to elucidate the mechanisms underlying autoimmunity and allergy.
In particular:
1) Uncovering the diverse role of IL-21, a pleiotropic cytokine, across various immune reactions and deciphering the regulatory mechanisms behind IL-21 production.
2) Elucidating the functions of Sox family molecules, identified during the process mentioned in 1), in the differentiation of helper T cells and regulatory T cells.
3) Investigating the mechanism of action of methotrexate, a key therapeutic agent for rheumatoid arthritis.
Recent Topics of Interests:
The development and maintenance of IL-17-producing γδT cells (γδT17 cells) and their role in autoimmunity and tumor immunity
Motto in Research or in Life: The truth is in the details / Let it be
Hobby / Holiday: Tennis, Jogging, Housework, Playing with my Cat
Graduate School of Medicine, Chiba University
Associate ProfessorI embarked on an academic path driven by my fascination with stem cells, renowned for their remarkable regenerative and differentiation capabilities. Presently, I am dedicated to advancing research in regenerative medicine and developing pathological models utilizing various types of human stem cells, with the ultimate goal of their clinical application in medical treatments.
Recent Topics of Interests:
Regenerative medicine, Hematopoietic stem cells, Aging-related diseases, Rejuvenation of an organism
Institute for Advanced Academic Research / Graduate School of Medicine, Chiba University
Associate ProfessorI conduct research aimed at discovering diagnostic markers and therapeutic targets through integrating clinical information and omics data, such as comprehensive gene expression (transcriptome) and protein expression (proteome) using clinical specimens. Additionally, I work on elucidating the regulatory mechanisms of gene expression during the differentiation process by using cell models.
Recent Topics of Interests: Stratification and prognostication of disease based on omics data
Motto in Research or in Life: Spirit of a rag (a willingness to contribute to society even at the cost of personal sacrifice)
Hobby / Holiday: I feel happiest when I spend time with my family.
