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Institute for Advanced Academic Research / Graduate School of Medicine / Research Institute of Disaster Medicine, Chiba University
ProfessorThe genome is the blueprint of life. The “which part” of the genome is read differs in each cell, and the addition or deletion of the methyl group CH3- (just four atoms) plays an important role in reading the genome. This mechanism is known as epigenetic modification, and the development of next-generation sequencing technology has greatly contributed to this research field. Epigenetic modifications by methyl groups can be classified into two types: (1) methylation of histones and (2) methylation of DNA cytosines. Our previous research showed that histone methylations regulated by the Polycomb and Trithorax group proteins are essential for immune responses, particularly those mediated by T cells. In addition, our recent international collaborative study revealed that TET enzymes, which convert methyl-cytosine into hydroxymethyl-cytosine, inhibit inflammation and tumor development in mice and humans. Currently, our study focuses on the relationship between age-related epigenetic abnormalities and immune diseases, which has received much attention in recent years. The final goal of my research is to solve the mysteries of life and ultimately control diseases by concentrating our wisdom on physics, chemistry, and mathematics.
Recent Topics of Interests:
Cancer immunotherapy by epigenetic manipulation, Immuno-aging caused by epigenetic abnormalities, Integrative single-cell multi-omics analyses
Motto in Research or in Life:
The motto in research: Let’s enjoy science!
The motto in life: “If you put your mind to it, you could accomplish anything.” This quote is cited from Back to the Future, Universal Pictures, 1985.
Hobby / Holiday:
Reading books, Watching baseball games, Insect hunting
Institute for Advanced Academic Research / Graduate School of Social Sciences, Chiba University
Professor / Director, Center for Relational Studies on Global Crises Studies on contemporary politics in the Middle East, with a specific focus on Iraq and its relation with the international politics. I am eager to work on any subject that allows me to comprehend the dynamics of the Middle Eastern politics, mobilizing any kinds of disciplines. Furthermore, I aim to grasp the dynamics of international politics that contribute to form the region of the “Middle East”, with a particular emphasis on relationships (Relational Studies on Global Crises).
Recent Topics of Interest:
People’s protest movements on the streets in Middle Eastern countries. I would like to examine the messages they are conveying through wall graffiti, placards, SNS hashtags, and other means, as well as the networks and solidarity these messages create among ordinary people.
Motto in Research or in Life:
Rolling the ball: Seeing a ball rolling in front of me without anyone kicking it, I can’t help but feel that it represents a lack of courage, so I end up kicking it myself.
Hobby / Holiday:
While listening to music, I’m actively striving to stay connected with the local daily life in the Middle East, particularly in Iraq.
Institute for Advanced Academic Research / Graduate School of Science, Chiba University
Assistant ProfessorAnimals often appear to adhere to certain behavioral rules, yet they exhibit distinct behavioral patterns among individuals, called personalities. Such diversity among individuals can be beneficial for a group. I am investigating the molecular and evolutionary mechanisms behind the emergence of behavioral diversity, possibly providing insights into our societies.
Recent Topics of Interests: Genetics behind emergent properties of collective behavior.
Motto in Research or in Life: You are what you do.
Hobby / Holiday: Running, Badminton
Institute for Advanced Academic Research / Graduate School of Medicine, Chiba University
Associate ProfessorMy research aims to elucidate the mechanisms underlying autoimmunity and allergy.
In particular:
1) Uncovering the diverse role of IL-21, a pleiotropic cytokine, across various immune reactions and deciphering the regulatory mechanisms behind IL-21 production.
2) Elucidating the functions of Sox family molecules, identified during the process mentioned in 1), in the differentiation of helper T cells and regulatory T cells.
3) Investigating the mechanism of action of methotrexate, a key therapeutic agent for rheumatoid arthritis.
Recent Topics of Interests:
The development and maintenance of IL-17-producing γδT cells (γδT17 cells) and their role in autoimmunity and tumor immunity
Motto in Research or in Life: The truth is in the details / Let it be
Hobby / Holiday: Tennis, Jogging, Housework, Playing with my Cat
Institute for Advanced Academic Research / Graduate School of Engineering, Chiba University
ProfessorI am conducting research aimed at creating ‘meaningful structures’ in the mesoscale, which connects the nanoscale and microscale, through the assembly of molecules.
Given that crucial functions within living organisms heavily rely on mesoscale structures, my goal is to artificially fabricate such structures to generate novel functionalities.
Recent Topics of Interests:
Development of a method to assemble nanostructures into more complex hierarchical structures
Motto in Research or in Life:
Not being afraid to fail
Respecting others
Hobby / Holiday: Searching for addicting music, Going out to places my kids love
Institute for Advanced Academic Research / Graduate School of Medicine, Chiba University
Associate ProfessorI conduct research aimed at discovering diagnostic markers and therapeutic targets through integrating clinical information and omics data, such as comprehensive gene expression (transcriptome) and protein expression (proteome) using clinical specimens. Additionally, I work on elucidating the regulatory mechanisms of gene expression during the differentiation process by using cell models.
Recent Topics of Interests: Stratification and prognostication of disease based on omics data
Motto in Research or in Life: Spirit of a rag (a willingness to contribute to society even at the cost of personal sacrifice)
Hobby / Holiday: I feel happiest when I spend time with my family.
